Optimizing the management of patients with small renal masses in a Canadian context: A Markov decision-analysis model.

ABSTRACT:

Introduction

The management of patients with a small renal mass (SRM) varies significantly. The objective of this study was to determine which initial management strategy resulted in the greatest quality-adjusted life months (QALM) for an index patient with a SRM.

Methods

A Markov decision analysis was used to determine the effect of 1) treating patients with a partial nephrectomy (PN); 2) active surveillance (AS); and 3) renal mass biopsy on QALM over a 10-year horizon. All relevant health states were modelled. Biopsy sensitivity and specificity were modelled assuming an 80% prevalence of cancer using procedural pathology as the gold standard. Health state utilities were obtained from the Tufts Medical Centre Cost-Effective Analysis Registry. Deterministic sensitivity analy

SUBMITTER: McAlpine K 

PROVIDER: S-EPMC8937603 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature