Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer.

ABSTRACT: Epithelial-mesenchymal plasticity (EMP) refers to the reversible cellular transition between epithelial and mesenchymal status. Spontaneous EMP is also reported in breast and prostate cancer, leading to the acquisition of stem-cell properties and chemoresistance. However, the presence of spontaneous EMP is still not reported in esophageal cancer. We screened 11 esophageal squamous cancer cell (ESCC) cell lines by CD44 isoform expression. KYSE520 was found to comprise heterogenous populations consisting of CD44v⁺ and CD44v^- subpopulations. CD44v⁺ and CD44v^- cells showed the expression of epithelial and mesenchymal markers, respectively. Single-cell sorting of CD44v⁺ and CD44v^- cells revealed both cells gave rise to cell popul

SUBMITTER: Tsuchihashi K 

PROVIDER: S-EPMC8938278 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature