Waning COVID-19 Vaccine Effectiveness for BNT162b2 and CoronaVac in Malaysia: An Observational Study.

ABSTRACT:

Objectives

We aimed to investigate and compare waning vaccine effectiveness (VE) against COVID-19 infection, COVID-19 related ICU admission, and COVID-19-related death for BNT162b2 and CoronaVac vaccines.

Methods

We consolidated national data on COVID-19 vaccination and outcomes, and used cases from September 1^st-30^th, 2021 to compare VE between the 'early' (fully vaccinated in April-June 2021) and 'late' (July-August 2021) groups. We estimated VE against COVID-19 infection with a negative binomial regression and VE against ICU admission and death among confirmed COVID-19 cases with a logistic regression.

Results

For BNT162b2, VE against COVID-19 infections declined from 90.8% (95% CI 89.4, 92.1) in the 'late' group to 79.3% (95% CI 76.1, 82.1) i

SUBMITTER: Suah JL 

PROVIDER: S-EPMC8938298 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature