Prenatal stress and its association with amygdala-related structural covariance patterns in youth.

ABSTRACT:

Background

Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared plasticity among regions. Childhood trauma is associated with amygdala-centric SCN reorganization patterns, however, the impact of prenatal stress on SCN properties remains unknown.

Methods

The study included participants from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with archival prenatal stress data and structural MRI acquired in young adulthood (age 23-24). SCNs were constructed based on Freesurfer-extracted volumes of 7 subcortical and 34 cortical regions. We compared amygdala degree centrality, a measure of hubnes

SUBMITTER: Mareckova K 

PROVIDER: S-EPMC8938327 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature