Simultaneous assessment of regional distributions of atrophy across the neuraxis in MS patients.

ABSTRACT:

Background

The ability to assess brain and cord atrophy simultaneously would improve the efficiency of MRI to track disease evolution.

Objective

To test a promising tool to simultaneously map the regional distribution of atrophy in multiple sclerosis (MS) patients across the brain and cord.

Methods

Voxel-based morphometry combined with a statistical parametric mapping probabilistic brain-spinal cord (SPM-BSC) template was applied to standard T1-weighted magnetic resonance imaging (MRI) scans covering the brain and cervical cord from 37 MS patients and 20 healthy controls (HC). We also measured the cord area at C2-C3 with a semi-automatic segmentation method using (i) the same T1-weighted acquisitions used for the new voxel-based analysis and (ii) dedicated spinal cord

SUBMITTER: Freund P 

PROVIDER: S-EPMC8938332 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature