Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in ¹⁸F-flortaucipir vs. ¹⁸F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (N_M) in 289 symptomatic patients from the Alzheimer's Disease Neuroimaging Initiative. We identified six T/N_M clusters with differing limbic and cortical patterns. The canonical group was defined as the T/N_M pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected relative to T and displayed better

SUBMITTER: Duong MT 

PROVIDER: S-EPMC8938426 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature