Associations among locus coeruleus catecholamines, tau pathology, and memory in aging.

ABSTRACT: The locus coeruleus (LC) is the brain's major source of the neuromodulator norepinephrine, and is also profoundly vulnerable to the development of Alzheimer's disease (AD)-related tau pathology. Norepinephrine plays a role in neuroprotective functions that may reduce AD progression, and also underlies optimal memory performance. Successful maintenance of LC neurochemical function represents a candidate mechanism of protection against the propagation of AD-related pathology and may facilitate the preservation of memory performance despite pathology. Using [¹⁸F]Fluoro-m-tyrosine ([¹⁸F]FMT) PET imaging to measure catecholamine synthesis capacity in LC regions of interest, we examined relationships among LC neurochemical function, AD-related pathology, and memory performa

SUBMITTER: Ciampa CJ 

PROVIDER: S-EPMC8938463 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature