Dynamic alterations in the lung microbiota in a rat model of lipopolysaccharide-induced acute lung injury.

ABSTRACT: The lung microbiota have been found to be substantially altered in numerous pulmonary disorders, and crosstalk between the host pathophysiology and lung microbiota plays critical roles in the regulation of disease states. The aim of this study was to investigate dynamic changes in the lung microbiota during different stages of acute lung injury and acute respiratory distress syndrome (ALI/ARDS). Rats receiving an intraperitoneal administration of lipopolysaccharide (LPS) were sacrificed at 12 and 48 h after injection, and the hematological parameters, serum cytokine levels, and histological characteristics of the lung tissue and lung microbiota were assessed. After LPS injection, along with fluctuations of systemic cytokine levels and the onset and regression of pulmonary edema, the divers

SUBMITTER: Tian Z 

PROVIDER: S-EPMC8938502 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature