Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures.

ABSTRACT: Parkinson's disease (PD) is a multi-stage neurodegenerative disorder with largely unknown etiology. Recent findings have identified PD-associated autoimmune features including roles for T cells. To further characterize the role of T cells in PD, we performed RNA sequencing on PBMC and peripheral CD4 and CD8 memory T cell subsets derived from PD patients and age-matched healthy controls. When the groups were stratified by their T cell responsiveness to alpha-synuclein (α-syn) as a proxy for an ongoing inflammatory autoimmune response, the study revealed a broad differential gene expression profile in memory T cell subsets and a specific PD associated gene signature. We identified significant enrichment of transcriptomic signatures previously associated with PD, including for oxidative stres

SUBMITTER: Dhanwani R 

PROVIDER: S-EPMC8938520 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature