Pan-cancer analysis of necroptosis-related gene signature for the identification of prognosis and immune significance.

ABSTRACT:

Background

Necroptosis is a novel programmed cell death mode independent on caspase. A number of studies have revealed that the induction of necroptosis could act as an alternative therapeutic strategy for drug-resistant tumors as well as affect tumor immune microenvironment.

Methods

Gene expression profiles and clinical data were downloaded from XENA-UCSC (including The Cancer Genome Atlas and Genotype-Tissue Expression), Gene Expression Omnibus, International Cancer Genome Consortium and Chinese Glioma Genome Atlas. We used non-negative matrix factorization method to conduct tumor classification. The least absolute shrinkage and selection operator regression was applied to establish risk models, whose prognostic effectiveness was examined in both training and testing sets

SUBMITTER: Ma J 

PROVIDER: S-EPMC8938586 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature