Child growth and neurodevelopment after maternal antenatal antibiotic treatment.

ABSTRACT:

Objective

To assess whether intermittent preventive treatment of pregnant women (IPTp) with sulfadoxine-pyrimethamine (SP) and azithromycin (AZI) in a malaria-endemic area leads to sustained gains in linear growth and development in their offspring.

Design

Follow-up study of a randomised trial.

Setting

Mangochi District in rural southern Malawi.

Participants

1320 pregnant women and their offspring.

Interventions

IPTp monthly with SP and twice with AZI (AZI-SP group), monthly with SP but no AZI (monthly SP), or twice with SP (control). No intervention was given to children.

Main outcome measures

Cognitive performance using Raven's Coloured Progressive Matrices (CPM) at 13 years of age; mean height and height-for-age Z-score (HAZ), cumulative incide

SUBMITTER: Videman K 

PROVIDER: S-EPMC8938655 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature