Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction Among Asian Women.

ABSTRACT:

Importance

Polygenic risk scores (PRSs) have shown promise in breast cancer risk prediction; however, limited studies have been conducted among Asian women.

Objective

To develop breast cancer risk prediction models for Asian women incorporating PRSs and nongenetic risk factors.

Design, setting, and participants

This diagnostic study included women of Asian ancestry from the Asia Breast Cancer Consortium. PRSs were developed using data from genomewide association studies (GWASs) of breast cancer conducted among 123 041 women with Asian ancestry (including 18 650 women with breast cancer) using 3 approaches: (1) reported PRS for women with European ancestry; (2) breast cancer-associated single-nucleotide variations (SNVs) identified by fine-mapping of GWAS-identified ri

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8938714 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature