Particulate hexavalent chromium alters microRNAs in human lung cells that target key carcinogenic pathways.

ABSTRACT: Hexavalent chromium [Cr(VI)] is a global environmental pollutant and human lung carcinogen. However, the mechanisms of Cr(VI) carcinogenesis are not well defined. Cr(VI)-altered gene expression has been reported in the literature and is implicated in numerous mechanisms of Cr(VI) carcinogenesis. MicroRNAs (miRNAs) play a key role in controlling gene expression and are associated with carcinogenic mechanisms. To date no studies have evaluated global changes in miRNA expression in human cells after Cr(VI) exposure. We used RNA sequencing to evaluate how a particulate Cr(VI) compound (zinc chromate), the most potent form of Cr(VI), alters global miRNA expression after acute (24 h) or prolonged (72 and 120 h) exposure to 0.1, 0.2 and 0.3 μg/cm² zinc chromate in an immortalized, non-

SUBMITTER: Speer RM 

PROVIDER: S-EPMC8938933 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature