Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents.

ABSTRACT: We describe the use of phenyl trimethylammonium iodide (PhMe₃NI) as an alternative methylating agent for introducing a CH₃ group in α-position to a carbonyl group. Compared to conventional methylating agents, quaternary ammonium salts have the advantages of being nonvolatile, noncancerogenic, and easy-to-handle solids. This regioselective method is characterized by ease of operational setup, use of anisole as green solvent, and yields up to 85%.

SUBMITTER: Templ J 

PROVIDER: S-EPMC8938946 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature