Proof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota.

ABSTRACT: Circadian misalignment-the misalignment between the central circadian "clock" and behavioral and environmental cycles (including sleep/wake, fasting/eating, dark/light)-results in adverse cardiovascular and metabolic effects. Potential underlying mechanisms for these adverse effects include alterations in the orogastrointestinal microbiota. However, it remains unknown whether human oral microbiota has endogenous circadian rhythms (i.e., independent of sleep/wake, fasting/eating, and dark/light cycles) and whether circadian misalignment influences oral microbiota community composition. Healthy young individuals [27.3 ± 2.3 years (18-35 years), 4 men and 2 women, body-mass index range: 18-28 kg/m² ] were enrolled in a stringently controlled 14-day circadian laboratory protocol. Th

SUBMITTER: Chellappa SL 

PROVIDER: S-EPMC8938955 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature