Patterns of recombinant growth hormone therapy use and growth responses among children with chronic kidney disease.

ABSTRACT:

Background

Recombinant growth hormone (rGH) is an efficacious therapy for growth failure in children with chronic kidney disease (CKD). We described rGH use and estimated its relationship with growth and kidney function in the Chronic Kidney Disease in Children (CKiD) cohort.

Methods

Participants included those with growth failure, prevalent rGH users, and rGH initiators who did not meet growth failure criteria. Among those with growth failure, height z scores and GFR were compared between rGH initiators and non-initiators across 42 months. Inverse probability weights accounted for differences in baseline variables in weighted linear regressions.

Results

Among 148 children with growth failure and no previous rGH therapy, 42 (28%) initiated rGH therapy. Of the initiato

SUBMITTER: Ng DK 

PROVIDER: S-EPMC8938997 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature