The innate immune receptor Nlrp12 suppresses autoimmunity to the retina.

ABSTRACT:

Background

Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined. The NLR, Nlrp12, has been reported to both inhibit and promote neuroinflammation in an animal model of multiple sclerosis (experimental autoimmune encephalomyelitis, EAE), where its T cell-specific role has been investigated. Uveitis resulting from autoimmunity of the neuroretina, an extension of the CNS, involves a breach in immune privilege and entry of T cells into the eye. Here, we examined the contribution of Nlrp12 in a T cell-mediated model of uveitis, experimental autoimmune uveitis (EAU).

Methods

Mice were immunized with interphotorecept

SUBMITTER: Lee EJ 

PROVIDER: S-EPMC8939070 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature