The Xenopus phenotype ontology: bridging model organism phenotype data to human health and development.

ABSTRACT:

Background

Ontologies of precisely defined, controlled vocabularies are essential to curate the results of biological experiments such that the data are machine searchable, can be computationally analyzed, and are interoperable across the biomedical research continuum. There is also an increasing need for methods to interrelate phenotypic data easily and accurately from experiments in animal models with human development and disease.

Results

Here we present the Xenopus phenotype ontology (XPO) to annotate phenotypic data from experiments in Xenopus, one of the major vertebrate model organisms used to study gene function in development and disease. The XPO implements design patterns from the Unified Phenotype Ontology (uPheno), and the principles outlined by the Open Biologic

SUBMITTER: Fisher ME 

PROVIDER: S-EPMC8939077 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature