Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer.

ABSTRACT:

Background

Increased epigenetic age acceleration (EAA) in survivors of childhood cancer is associated with specific treatment exposures, unfavorable health behaviors, and presence of certain chronic health conditions. To better understand inter-individual variability, we investigated the genetic basis underlying EAA.

Methods

Genome-wide association studies of EAA based on multiple epigenetic clocks (Hannum, Horvath, PhenoAge, and GrimAge) were performed. MethylationEPIC BeadChip array and whole-genome sequencing data were generated with blood-derived DNA from participants in the St. Jude Lifetime Cohort Study (discovery: 2138 pre-existing and 502 newly generated data, all survivors; exploratory: 282 community controls). Linear regression models were fit for each epigenetic a

SUBMITTER: Dong Q 

PROVIDER: S-EPMC8939156 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature