Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling.

ABSTRACT:

Background

Arsenic, existing ubiquitously in soil, drinking water, or food, is well known to be an environmental pollutants concerned by European Food Safety Authority. Lentinan, a beta-1,6;1,3-glucan extracts from Lentinus edodes, which has the properties of antioxidant and immunomodulation, present study explored the pharmacological effects of Lentinan on arsenic induced hepatotoxicity in mice.

Methods

Mice experiments were performed by sodium arsenite (SA) treatment or Lentinan intervention, then histopathology, ELISA, Flow Cytometry, or Western-Blotting were applied to evaluate hepatic injury, oxidative stress, CD4⁺ type 17 helper T (Th17) cells, CD4⁺CD25⁺Foxp3⁺ regulatory T cells (Tregs), T cells receptor OX40/CD134, IL-17A, N

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8939159 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature