Correlation between microRNA-320 and postoperative delirium in patients undergoing tibial fracture internal fixation surgery.

ABSTRACT:

Background

Although the incidence of postoperative delirium (POD) in the elderly after surgery are rising as individuals are living longer, the pathogenesis of POD remains poorly understood. It has been suggested that miRNA-320 may play a role in POD based on animal study and human study.

Methods

We first carried out an animal study, and designed and conducted a human study based on the result of animal study. The aged rats were randomly assigned to five groups: the control (C), anesthesia and surgery (AS), saline (NS), agomir-320 (AG), and antagomir-320 (AT) groups. Postoperative spatial learning and memory in rats were analyzed by the Morris water maze and the open field tests. The plasma levels of insulin-like growth factor-1 (IGF-1), amyloid precursor protein (APP) prote

SUBMITTER: Wang B 

PROVIDER: S-EPMC8939177 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature