Personalization of renal replacement therapy initiation: a secondary analysis of the AKIKI and IDEAL-ICU trials.

ABSTRACT:

Background

Trials comparing early and delayed strategies of renal replacement therapy in patients with severe acute kidney injury may have missed differences in survival as a result of mixing together patients at heterogeneous levels of risks. Our aim was to evaluate the heterogeneity of treatment effect on 60-day mortality from an early vs a delayed strategy across levels of risk for renal replacement therapy initiation under a delayed strategy.

Methods

We used data from the AKIKI, and IDEAL-ICU randomized controlled trials to develop a multivariable logistic regression model for renal replacement therapy initiation within 48 h after allocation to a delayed strategy. We then used an interaction with spline terms in a Cox model to estimate treatment effects across the predic

SUBMITTER: Grolleau F 

PROVIDER: S-EPMC8939225 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature