Sympathetic vasoconstrictor activity before and after left ventricular assist device implantation in patients with end-stage heart failure.

ABSTRACT:

Aims

Sympathetic overactivity, which predicts poor outcome in patients with heart failure, normalizes following cardiac transplantation. We tested the hypothesis that haemodynamic improvement following left ventricular assist device (LVAD) implantation is also associated with reductions in centrally generated sympathetic activity.

Methods and results

In eight patients with heart failure (two women, six men, age 44-66 years), we continuously recorded electrocardiogram, beat-to-beat finger blood pressure, respiration, and muscle sympathetic nerve activity (MSNA) before and after implantation of the continuous-flow LVAD devices HeartWare HVAD (n = 4) and HeartMate II (n = 2), and the non-continuous-flow device HeartMate 3 (n = 2). LVAD implantation increased cardiac output by 1

SUBMITTER: Heusser K 

PROVIDER: S-EPMC8939843 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature