TiO₂ nanoparticles generate superoxide and alter gene expression in human lung cells.

ABSTRACT: TiO₂ nanoparticles are widely used in consumer products and industrial applications, yet little is understood regarding how the inhalation of these nanoparticles impacts long-term health. This is especially important for the occupational safety of workers who process these materials. We used RNA sequencing to probe changes in gene expression and fluorescence microscopy to image intracellular reactive oxygen species (ROS) in human lung cells incubated with low, non-cytotoxic, concentrations of TiO₂ nanoparticles. Experiments were designed to measure changes in gene expression following an acute exposure to TiO₂ nanoparticles and changes inherited by progeny cells. We observe that TiO₂ nanoparticles lead to significant (>2000 differentially express

SUBMITTER: Jayaram DT 

PROVIDER: S-EPMC8939877 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature