Value and prognostic impact of a deep learning segmentation model of COVID-19 lung lesions on low-dose chest CT.

ABSTRACT:

Objectives

1) To develop a deep learning (DL) pipeline allowing quantification of COVID-19 pulmonary lesions on low-dose computed tomography (LDCT). 2) To assess the prognostic value of DL-driven lesion quantification.

Methods

This monocentric retrospective study included training and test datasets taken from 144 and 30 patients, respectively. The reference was the manual segmentation of 3 labels: normal lung, ground-glass opacity(GGO) and consolidation(Cons). Model performance was evaluated with technical metrics, disease volume and extent. Intra- and interobserver agreement were recorded. The prognostic value of DL-driven disease extent was assessed in 1621 distinct patients using C-statistics. The end point was a combined outcome defined as death, hospitalization>10 days,

SUBMITTER: Bartoli A 

PROVIDER: S-EPMC8939894 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature