Distinguishing Benign Renal Tumors with an Oncocytic Gene Expression (ONEX) Classifier.

ABSTRACT: Renal oncocytoma (RO) accounts for 5% of renal cancers and generally behaves as a benign tumor with favorable long-term prognosis. It is difficult to confidently distinguish between benign RO and other renal malignancies, particularly chromophobe renal cell carcinoma (chRCC). Therefore, RO is often managed aggressively with surgery. We sought to identify molecular biomarkers to distinguish RO from chRCC and other malignant renal cancer mimics. In a 44-patient discovery cohort, we identified a significant differential abundance of nine genes in RO relative to chRCC. These genes were used to train a classifier to distinguish RO from chRCC in an independent 57-patient cohort. The trained classifier was then validated in five independent cohorts comprising 89 total patients. This nine-gene cla

SUBMITTER: McGillivray PD 

PROVIDER: S-EPMC8939926 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature