Risk of heart disease following treatment for breast cancer - results from a population-based cohort study.

ABSTRACT: There is a rising concern about treatment-associated cardiotoxicities in breast cancer patients. This study aimed to determine the time- and treatment-specific incidence of arrhythmia, heart failure, and ischemic heart disease in women diagnosed with breast cancer. A register-based matched cohort study was conducted including 8015 breast cancer patients diagnosed from 2001 to 2008 in the Stockholm-Gotland region and followed up until 2017. Time-dependent risks of arrhythmia, heart failure, and ischemic heart disease in breast cancer patients were assessed using flexible parametric models as compared to matched controls from general population. Treatment-specific effects were estimated in breast cancer patients using Cox model. Time-dependent analyses revealed long-term increased risks of a

SUBMITTER: Yang H 

PROVIDER: S-EPMC8940173 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature