Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration.

ABSTRACT: Retinitis Pigmentosa (RP) is a progressive, debilitating visual disorder caused by mutations in a diverse set of genes. In both humans with RP and mouse models of RP, rod photoreceptor dysfunction leads to loss of night vision, and is followed by secondary cone photoreceptor dysfunction and degeneration, leading to loss of daylight color vision. A strategy to prevent secondary cone death could provide a general RP therapy to preserve daylight color vision regardless of the underlying mutation. In mouse models of RP, cones in the peripheral retina survive long-term, despite complete rod loss. The mechanism for such peripheral cone survival had not been explored. Here, we found that active retinoic acid (RA) signaling in peripheral Muller glia is necessary for the abnormally long survival of

SUBMITTER: Amamoto R 

PROVIDER: S-EPMC8940176 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature