A Computational Framework for Studying Gut-Brain Axis in Autism Spectrum Disorder.

ABSTRACT:

Introduction

The integrity of the intestinal epithelium is crucial for human health and is harmed in autism spectrum disorder (ASD). An aberrant gut microbial composition resulting in gut-derived metabolic toxins was found to damage the intestinal epithelium, jeopardizing tissue integrity. These toxins further reach the brain via the gut-brain axis, disrupting the normal function of the brain. A mechanistic understanding of metabolic disturbances in the brain and gut is essential to design effective therapeutics and early intervention to block disease progression. Herein, we present a novel computational framework integrating constraint based tissue specific metabolic (CBM) model and whole-body physiological pharmacokinetics (PBPK) modeling for ASD. Furthermore, the role of

SUBMITTER: Mohammad FK 

PROVIDER: S-EPMC8940246 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature