Etiologic Classification of 541 Infantile Spasms Cases: A Cohort Study.

ABSTRACT:

Objective

To explore the etiology of infantile spasms (IS) in a large Chinese cohort based on the United States National Infantile Spasms Consortium (NISC) classification.

Methods

In the present study, we recruited IS patients diagnosed at a single center (Xiangya Hospital, Central South University) between Jan 2010 and Aug 2019. Thereafter, we collected their clinical and genetic information retrospectively. Their underlying etiologies were classified according to the NISC classification and then compared in different scenarios to understand their distribution.

Results

A total of 541 patients with IS from 18 provinces were included in this study. The underlying etiology was identified in 53.2% of the cases: structural-acquired, 25.3%; genetic, 12.9%; genetic-structur

SUBMITTER: Peng P 

PROVIDER: S-EPMC8940518 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature