The essential role for endothelial cell sprouting in coronary collateral growth.

ABSTRACT:

Rationale

Coronary collateral growth is a natural bypass for ischemic heart diseases. It offers tremendous therapeutic benefit, but the process of coronary collateral growth isincompletely understood due to limited preclinical murine models that would enable interrogation of its mechanisms and processes via genetic modification and lineage tracing. Understanding the processes by which coronary collaterals develop can unlock new therapeutic strategies for ischemic heart disease.

Objective

To develop a murine model of coronary collateral growth by repetitive ischemia and investigate whether capillary endothelial cells could contribute to the coronary collateral formation in an adult mouse heart after repetitive ischemia by lineage tracing.

Methods and results

A murine m

SUBMITTER: Jamaiyar A 

PROVIDER: S-EPMC8940680 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature