Comparison of prefrontal cortex sucrose seeking ensembles engaged in multiple seeking sessions: Context is key.

ABSTRACT: Encoding of memories, including those associated with prior drug or reward, is thought to take place within distinct populations of neurons, termed ensembles. Neuronal ensembles for drug- and reward-seeking have been identified in regions of the medial prefrontal cortex, but much of our understanding of these ensembles is based on experiments that take place in a single reward-associated environment and measure ensemble encoding over short durations of time. In contrast, reward seeking behavior is evident across different reward-associated environments and persists over time. Using TetTag mice and Fos immunohistochemistry, we examined the relationship between persistent sucrose-seeking and ensemble encoding in mice that undergo seeking sessions in the same or different sucrose self-adminis

SUBMITTER: Jessen K 

PROVIDER: S-EPMC8940716 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature