Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos.

ABSTRACT:

Background

Inwardly rectifying potassium channels are essential for normal potassium homeostasis, maintaining the cellular resting membrane potential, and regulating electrolyte transportation. Mutations in Kir channels have been known to cause debilitating diseases ranging from neurological abnormalities to renal and cardiac failures. Many efforts have been made to understand their protein structures, physiological functions, and pharmacological modifiers. However, their expression and functions during embryonic development remain largely unknown.

Results

Using zebrafish as a model, we identified and renamed 31 kir genes. We also analyzed Kir gene evolution by phylogenetic and syntenic analyses. Our data indicated that the four subtypes of the Kir genes might have already e

SUBMITTER: Silic MR 

PROVIDER: S-EPMC8940742 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature