High-resolution pediatric age-specific ¹⁸F-FDG PET template: a pilot study in epileptogenic focus localization.

ABSTRACT:

Background

PET imaging has been widely used in diagnosis of neurological disorders; however, its application to pediatric population is limited due to lacking pediatric age-specific PET template. This study aims to develop a pediatric age-specific PET template (PAPT) and conduct a pilot study of epileptogenic focus localization in pediatric epilepsy.

Methods

We recruited 130 pediatric patients with epilepsy and 102 age-matched controls who underwent ¹⁸F-FDG PET examination. High-resolution PAPT was developed by an iterative nonlinear registration-averaging optimization approach for two age ranges: 6-10 years (n = 17) and 11-18 years (n = 50), respectively. Spatial normalization to the PAPT was evaluated by registration similarities of 35 validation controls, follo

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8940757 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature