Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review.

ABSTRACT:

Purpose

To assess the ability of clinical examination, blood biomarkers, electrophysiology or neuroimaging assessed within 7 days from return of spontaneous circulation (ROSC) to predict good neurological outcome, defined as no, mild, or moderate disability (CPC 1-2 or mRS 0-3) at discharge from intensive care unit or later, in comatose adult survivors from cardiac arrest (CA).

Methods

PubMed, EMBASE, Web of Science and the Cochrane Database of Systematic Reviews were searched. Sensitivity and specificity for good outcome were calculated for each predictor. The risk of bias was assessed using the QUIPS tool.

Results

A total of 37 studies were included. Due to heterogeneities in recording times, predictor thresholds, and definition of some predictors, meta-analysis was

SUBMITTER: Sandroni C 

PROVIDER: S-EPMC8940794 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature