Prospective analysis of clinically significant prostate cancer detection with [¹⁸F]DCFPyL PET/MRI compared to multiparametric MRI: a comparison with the histopathology in the radical prostatectomy specimen, the ProStaPET study.

ABSTRACT:

Purpose

Multiparametric magnetic resonance imaging (mpMRI) is a well-established imaging method for localizing primary prostate cancer (PCa) and for guiding targeted prostate biopsies. [¹⁸F]DCFPyL positron emission tomography combined with MRI (PSMA-PET/MRI) might be of additional value to localize primary PCa. The aim of this study was to assess the diagnostic performance of [¹⁸F]DCFPyL-PET/MRI vs. mpMRI in tumour localization based on histopathology after robot-assisted radical-prostatectomy (RARP), also assessing biopsy advice for potential image-guided prostate biopsies.

Methods

Thirty prospectively included patients with intermediate to high-risk PCa underwent [¹⁸F]DCFPyL-PET/MRI and mpMRI prior to RARP. Two nuclear medicine physicians a

SUBMITTER: Bodar YJL 

PROVIDER: S-EPMC8940822 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature