Visualization of thermal damage using ⁶⁸ Ga-FAPI-PET/CT after pulmonary vein isolation.

ABSTRACT:

Purpose

⁶⁸ Ga-fibroblast-activation protein inhibitor (FAPI) positron emission tomography (PET) is a novel technique targeting FAP-alpha. This protein is expressed by activated fibroblasts which are the main contributors to tissue remodeling. The aim of this proof-of-concept study was to assess ⁶⁸ Ga-FAPI uptake in the pulmonary vein (PV) region of the left atrium after pulmonary vein isolation (PVI) with cryoballoon ablation (CBA) and radiofrequency (RFA) as a surrogate for thermal damage.

Methods

Twelve PVI patients (5 RFA, 7 CBA) underwent ⁶⁸ Ga-FAPI-PET 20.5 ± 12.8 days after PVI. Five patients without atrial fibrillation or previous ablation served as controls. Standardized uptake values of localized tracer uptake were calculated.

Res

SUBMITTER: Kupusovic J 

PROVIDER: S-EPMC8940837 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature