About prestretch in homogenized constrained mixture models simulating growth and remodeling in patient-specific aortic geometries.

ABSTRACT: Evolution of mechanical and structural properties in the Ascending Thoracic Aorta (ATA) is the results of complex mechanobiological processes. In this work, we address some numerical challenges in order to elaborate computational models of these processes. For that, we extend the state of the art of homogenized constrained mixture (hCM) models. In these models, prestretches are assigned to the mixed constituents in order to ensure local mechanical equilibrium macroscopically, and to maintain a homeostatic level of tension in collagen fibers microscopically. Although the initial prestretches were assumed as homogeneous in idealized straight tubes, more elaborate prestretch distributions need to be considered for curved geometrical models such as patient-specific ATA. Therefore, we introduce

SUBMITTER: Laubrie JD 

PROVIDER: S-EPMC8940846 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature