Mechanisms underlying interactions between two abundant oral commensal bacteria.

ABSTRACT: Complex polymicrobial biofilm communities are abundant in nature particularly in the human oral cavity where their composition and fitness can affect health. While the study of these communities during disease is essential and prevalent, little is known about interactions within the healthy plaque community. Here we describe interactions between two of the most abundant species in this healthy microbiome, Haemophilus parainfluenzae and Streptococcus mitis. We discovered that H. parainfluenzae typically exists adjacent to mitis group streptococci in vivo with which it is also positively correlated based on microbiome data. By comparing in vitro coculture data to ex vivo microscopy we revealed that this co-occurrence is density dependent and further influenced by H₂O₂ p

SUBMITTER: Perera D 

PROVIDER: S-EPMC8940909 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature