PD-L1 expression in EBV associated gastric cancer: a systematic review and meta-analysis.

ABSTRACT:

Objectives

The aim of this systematic review and meta-analysis is to the summarize the evidence on programmed cell death protein ligand 1 (PD-L1) in Epstein-Barr virus associated gastric cancer (EBVaGC) and to estimate the expression rate of PD-L1 among this subtype of Gastric Cancer (GC).

Materials and methods

For this study, PubMed^®, EMBASE^® and Web of Science^® databases were searched for articles published until 1st November 2021. A total of 43 eligible publications with a total of 11,327 patients were included analysis based on inclusion and exclusion criteria. A total of 41 publications present data for proportion estimation and 33 for comparison of PD-L1 between EBV positive and negative GC. DerSimonian-Laird random-effects model was us

SUBMITTER: Lima A 

PROVIDER: S-EPMC8941030 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature