The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use.

ABSTRACT: Problematic alcohol use is a major contributor to the global burden of death and disabilities, and it represents a public health concern that has grown substantially following the COVID-19 pandemic. The available treatment options remain limited and to develop better pharmacotherapies for alcohol misuse we need to identify suitable biological targets. Previous research has implicated the brain's endocannabinoid system (ECS) in psychiatric and stress-related outcomes, including substance use and habituation to repeated stress. Moreover, genetic variants in the cannabinoid-1 receptor gene (CNR1; CB1R) have been associated with personality traits, which are in turn predictors of substance use disorders. To date, however, no human genome-wide association study has provided evidence for an invo

SUBMITTER: Bornscheuer L 

PROVIDER: S-EPMC8941304 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature