Lipid traits and type 2 diabetes risk in African ancestry individuals: A Mendelian Randomization study.

ABSTRACT:

Background

Dyslipidaemia is highly prevalent in individuals with type 2 diabetes mellitus (T2DM). Numerous studies have sought to disentangle the causal relationship between dyslipidaemia and T2DM liability. However, conventional observational studies are vulnerable to confounding. Mendelian Randomization (MR) studies (which address this bias) on lipids and T2DM liability have focused on European ancestry individuals, with none to date having been performed in individuals of African ancestry. We therefore sought to use MR to investigate the causal effect of various lipid traits on T2DM liability in African ancestry individuals.

Methods

Using univariable and multivariable two-sample MR, we leveraged summary-level data for lipid traits and T2DM liability from the African Partn

SUBMITTER: Soremekun O 

PROVIDER: S-EPMC8941323 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature