Dorsal visual stream is preferentially engaged during externally guided action selection in Parkinson Disease.

ABSTRACT:

Objective

In patients with Parkinson Disease (PD), self-initiated or internally cued (IC) actions are thought to be compromised by the disease process, as exemplified by impairments in action initiation. In contrast, externally-cued (EC) actions which are made in response to sensory prompts can restore a remarkable degree of movement capability in PD, particularly alleviating freezing-of-gait. This study investigates the electrophysiological underpinnings of movement facilitation in PD through visuospatial cuing, with particular attention to the dynamics within the posterior parietal cortex (PPC) and lateral premotor cortex (LPMC) axis of the dorsal visual stream.

Methods

Invasive cortical recordings over the PPC and LPMC were obtained during deep brain stimulation lead impl

SUBMITTER: Sparks H 

PROVIDER: S-EPMC8941338 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature