Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE).

ABSTRACT:

Objectives

To assess the effectiveness of prone positioning to reduce the risk of death or respiratory failure in non-critically ill patients admitted to hospital with covid-19.

Design

Multicentre pragmatic randomised clinical trial.

Setting

15 hospitals in Canada and the United States from May 2020 until May 2021.

Participants

Eligible patients had a laboratory confirmed or a clinically highly suspected diagnosis of covid-19, needed supplemental oxygen (up to 50% fraction of inspired oxygen), and were able to independently lie prone with verbal instruction. Of the 570 patients who were assessed for eligibility, 257 were randomised and 248 were included in the analysis.

Intervention

Patients were randomised 1:1 to prone positioning (that is, instructing

SUBMITTER: Fralick M 

PROVIDER: S-EPMC8941343 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature