Prophylactic Oral Dextrose Gel and Neurosensory Impairment at 2-Year Follow-up of Participants in the hPOD Randomized Trial.

ABSTRACT:

Importance

Prophylactic oral dextrose gel reduces neonatal hypoglycemia, but later benefits or harms remain unclear.

Objective

To assess the effects on later development of prophylactic dextrose gel for infants born at risk of neonatal hypoglycemia.

Design, setting, and participants

Prospective follow-up of a multicenter randomized clinical trial conducted in 18 Australian and New Zealand hospitals from January 2015 to May 2019. Participants were late preterm or term at-risk infants; those randomized in 9 New Zealand centers (n = 1359) were included and followed up between January 2017 and July 2021.

Interventions

Infants were randomized to prophylactic 40% dextrose (n = 681) or placebo (n = 678) gel, 0.5 mL/kg, massaged into the buccal mucosa 1 hour after birt

SUBMITTER: Edwards T 

PROVIDER: S-EPMC8941358 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature