Extent of intravital contraction of arterial and venous thrombi and pulmonary emboli.

ABSTRACT: Blood clots and thrombi undergo platelet-driven contraction/retraction followed by structural rearrangements. We have established quantitative relationships between the composition of blood clots and extent of contraction to determine intravital contraction of thrombi and emboli based on their content. The composition of human blood clots and thrombi was quantified using histology and scanning electron microscopy. Contracting blood clots were segregated into the gradually shrinking outer layer that contains a fibrin-platelet mesh and the expanding inner portion with compacted red blood cells (RBCs). At 10% contraction, biconcave RBCs were partially compressed into polyhedral RBCs, which became dominant at 20% contraction and higher. The polyhedral/biconcave RBC ratio and the extent of cont

SUBMITTER: Khismatullin RR 

PROVIDER: S-EPMC8941457 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature