Sex-specific genetic modifiers identified susceptibility of cold stored red blood cells to osmotic hemolysis.

ABSTRACT:

Background

Genetic variants have been found to influence red blood cell (RBC) susceptibility to hemolytic stress and affect transfusion outcomes and the severity of blood diseases. Males have a higher susceptibility to hemolysis than females, but little is known about the genetic mechanism contributing to the difference.

Results

To investigate the sex differences in RBC susceptibility to hemolysis, we conducted a sex-stratified genome-wide association study and a genome-wide gene-by-sex interaction scan in a multi-ethnic dataset with 12,231 blood donors who have in vitro osmotic hemolysis measurements during routine blood storage. The estimated SNP-based heritability for osmotic hemolysis was found to be significantly higher in males than in females (0.46 vs. 0.41). We ident

SUBMITTER: Fang F 

PROVIDER: S-EPMC8941732 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature