Starvation causes changes in the intestinal transcriptome and microbiome that are reversed upon refeeding.

ABSTRACT:

Background

The ability of animals and their microbiomes to adapt to starvation and then restore homeostasis after refeeding is fundamental to their continued survival and symbiosis. The intestine is the primary site of nutrient absorption and microbiome interaction, however our understanding of intestinal adaptations to starvation and refeeding remains limited. Here we used RNA sequencing and 16S rRNA gene sequencing to uncover changes in the intestinal transcriptome and microbiome of zebrafish subjected to long-term starvation and refeeding compared to continuously fed controls.

Results

Starvation over 21 days led to increased diversity and altered composition in the intestinal microbiome compared to fed controls, including relative increases in Vibrio and reductions in Ple

SUBMITTER: Jawahar J 

PROVIDER: S-EPMC8941736 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature