Association between statin use and physical performance in home-dwelling older patients receiving polypharmacy: cross-sectional study.

ABSTRACT:

Background

In older patients with polypharmacy and multiple comorbidities, even low grades of statin-associated muscle symptoms may have clinical implications. The aim of this study was therefore to investigate the potential associations between statin use and measures of physical performance and muscle function.

Methods

Participants were aged 70+, treated with at least seven regular systemic medications, and not expected to die or become institutionalized within 6 months. Physical performance measured as gait speed and Short Physical Performance Battery (SPPB) score, and muscle function measured as grip strength, were compared between users and non-users of statins. In the subgroup of statin users, the dose-response relationship was assessed using harmonized simvastatin equ

SUBMITTER: Veddeng S 

PROVIDER: S-EPMC8941743 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature