Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects.

ABSTRACT:

Background

The oral uptake of nanoparticles is an important route of human exposure and requires solid models for hazard assessment. While the systemic availability is generally low, ingestion may not only affect gastrointestinal tissues but also intestinal microbes. The gut microbiota contributes essentially to human health, whereas gut microbial dysbiosis is known to promote several intestinal and extra-intestinal diseases. Gut microbiota-derived metabolites, which are found in the blood stream, serve as key molecular mediators of host metabolism and immunity.

Results

Gut microbiota and the plasma metabolome were analyzed in male Wistar rats receiving either SiO₂ (1000 mg/kg body weight/day) or Ag nanoparticles (100 mg/kg body weight/day) during a 28-day oral ga

SUBMITTER: Landsiedel R 

PROVIDER: S-EPMC8941749 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature